AFP/HO |
Medicine
could be revolutionized by a UK project committed to mapping the DNA genetic
code of people with cancer and rare diseases.
The four-year project to
sequence 100,000 people’s DNA could lead to targeted therapies, making
treatments like chemotherapy "a
thing of the past.” Scientists believe our understanding of DNA
will soon play a role in every aspect of medicine.
The
genome of a participating patient's tumour will be scoured for differences with
the genetic code of their healthy tissue, while those with rare diseases will
have their DNA compared with that of close relatives. Fifteen thousand families
of people with rare diseases will take part in the project.
The
first genome was sequenced on May 30 by Genomics England, with the aim of
reaching 1,000 by the end of the year, and 10,000 by the end of 2015.
Lifting
hopes of finding the illusive cure for cancer, understanding how tumours are
caused by mutations in DNA will be central to the research. For example, breast
cancer is not one disease but at least 10, each with a different cause, life
expectancy and correct treatment.
The new research could potentially revolutionize methods of identifying and treating the disease.
The new research could potentially revolutionize methods of identifying and treating the disease.
“In
Britain we were the discoverers of the structure of DNA, we were huge players
in the human genome project and now the time has come for the next major step
forward,” said Sir John Chisholm, executive chair of
Genomics England.
“One
hundred thousand sequences is a very large step; it's a huge commitment.”
The
world-recognised centre of genetics research in Cambridge, the Wellcome Trust
Sanger Institute, will play host to Genomics England.
A
series of investments across government, industry and charities totalling £300
million was announced by PM David Cameron.
“I
am determined to do all I can to support the health and scientific sector to
unlock the power of DNA, turning an important scientific breakthrough into
something that will help deliver better tests, better drugs and above all
better care for patients,” he said.
“I believe we will be able to transform how
devastating diseases are diagnosed and treated in the NHS and across the
world.”
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